Monday, May 14, 2018

Hard to argue with this...

"My prediction that GWAS studies would turn up many replicable genetic hits for IQ "within 10 years" was correct. <- My last tweet to you. Bye."

-Stuart Ritchie, with a very thoughtful retort to my contention that GWAS studies are likely all false positives (shortly after calling me a "crank"). At least he actually responded. Notice, by the way, that he said, "replicable" and not replicated. Cute, that.


Addendum:
"Finally, it is also possible that, although specific loci reached genome-wide significance in particular studies, there are false positives, highlighting the importance of well-powered replication studies."

From a study published two weeks later and co-authored by Stuart Ritchie.

Tuesday, May 8, 2018

A Quick Review of a Dyslexia GWAS study claiming two significant loci

I will try to trim this review down to its barebones for an easier read, but welcome any comments or clarifications.  The study in question can be found here.

Genome Wide Association Scan identifies new variants associated with a cognitive predictor of dyslexia 

The study is on a much smaller scale, with only a few thousand cases, so one might expect fewer false positives.  In this case, likely we have two.