Another absurd GWAS:
Saturday, October 31, 2020
Yet Another Study Showing that Polygenic Scores are Confounded by Population Stratification
Another study related to height PGS:
Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies
It should at some point become clear that GWAS and their cousin, the "polygenic score" are little more than measures of population stratification and other such issues in the population being studied (or the database being used). In this case, here is the money shot:
More generally, our results imply that typical constructions of polygenic scores are sensitive to population stratification and that population-level differences should be interpreted with caution.
I would be grateful if someone could tell me what interpreting with caution would look like? How about stop making these interpretations, instead?
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