GWAS Catalog For Life!

Steve Pittelli <stevepittelli@gmail.com>	6:51 PM (19 hours ago)
to gwas-info

Hello there,
I was wondering what your policy is, regarding GWAS associations that are not subsequently replicated or are in some way refuted?  Do you ever remove them from the catalog or otherwise make a note of this?
Thanks,
Steve Pittelli

Annalisa Buniello <buniello@ebi.ac.uk>	9:29 AM (5 hours ago)
to me, gwas-info

Dear Steve,

Many thanks for your email and your interest in the GWAS Catalog.

As we also describe in our extraction methods https://www.ebi.ac.uk/gwas/docs/methods, individual SNP-trait associations identified in eligible publications are included in the Catalog only if they are statistically significant  (SNP-trait p-value <1.0 x 10-5) the in the overall (initial GWAS + replication) population. 

But if by not subsequently replicated you mean an association that is later found to not be valid, then the answer to your questions is no. We don’t remove the SNPs from the Catalog once they have been extracted from a previous publication that reported data from the original GWAS.

I hope this answers your question, but please don’t hesitate to contact us if you have further queries or comments on the GWAS Catalog.

Best wishes,

Annalisa

Annalisa Buniello, PhD
Scientific Curator
Open Targets and GWAS Catalog