This study just came out which used the Ancestry database to assess the genetic heritability of longevity, which has been previously formulated as upwards of 15 to 30%. They found that, in fact, taking away assortative mating it is below 10%. They used pedigrees and compared the in-law siblings.
A GWAS in such a scenario, then, would pick up a lot of extraneous, noncausal genetic associations that were really just related to commonalities from assortative mating, leading one to believe that these genes had some specific role for longevity and possibly wasting a researcher's time.
I would be interested in seeing a similar study on educational attainment, as I think it might very well show the same thing. I have, in fact, postulated just this in previous posts on here.
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