Wednesday, January 2, 2019

Genes for Ice Cream Flavor preference...

Yes, the bar gets lowered once again as it approaches a Coke vs. Pepsi gene.  This time we have a "study" that purports to find genes for a preference for chocolate vs. vanilla ice cream (and strawberry, of course).  I know, you are thinking I'm making this up, so here it is.  I'm pretty sure, back in the day, I considered using exactly this possibility to mock these studies, but opted on "finding raisins to be tasty."  I'll get a little bit into the study, but first, let me ask anyone reading this to try to catch yourself in that moment between when something absurd was stated and when you convince yourself that it is somehow valid because, you know, it's science and all.  I like to call that the "Emperor has no clothes!" moment.  Maybe that moment has already passed you by, so try, really try, to remember how you felt in those few seconds before you had to tuck it away.  That moment is important.  It's the brief time when one can see, no matter how much they've been inundated with "scientific" pronouncements to the contrary, that this entire field of study might just have a kind of absurdity to it.
Can't go there?  Well, then you have to believe that there are genetic variants for preferring chocolate or strawberry ice cream over vanilla.  Lot's of them, in fact.  Or you have to explain why this study is not valid and other GWAS studies are.  Let's go through this important study:
To garner which ice cream each of the participants in this 23andMe study preferred, they were asked:
"
  • “Which of the following ice cream flavors do you like best?”
Possible answers were “vanilla”, “chocolate”, “strawberry” or “other flavors or no ice cream”. With that important information at hand, they then did a couple of genome wide association studies, using vanilla as their "case," compared separately to both chocolate and strawberry.  In the chocolate version, they found "45 GENOME-WIDE SIGNIFICANT HITS!" [sarcastic emphasis and exclamation point, mine].  They've got Manhattan plots and everything.  Who would have thought that 45 genes would be involved in ice cream preference?  Well, if we're honest, here, absolutely no one.  It is patently absurd.  Did you have one of those moments again, where you realized it was absurd, then felt you had to accept the "science" and tucked it away?  
Hey, but they prove it, right, because 5 of those hits are NEAR the genes for olfactory receptors, (which we might call horseshoe receptors).  If you are following along, you might notice that this study is not really distinguishable from any of your usual GWAS studies for cognitive traits.  Thus, if you believe that such studies show, say, genes for IQ, then what reason do you have to disbelieve that these genes for preferring chocolate ice cream aren't also valid.  Perhaps, again, you had a brief moment when you questioned what this says about all of these studies (but, then you no doubt tucked it away).  Try again to remember that moment.
What you must certainly be wondering now is, "What about the strawberry ice cream GWAS?"  Were you wondering that? Well, they kind of cut things off, and don't tell us the full results, but rest assured that some of the hits for strawberry ice cream were also NEAR the olfactory receptors.  Case closed, folks.  Science. 
And, post-script, if you still aren't convinced, they point out that people who prefer dark chocolate, tend to prefer chocolate ice cream.  
To add another post-script, I think that we should see if there are any matches between the SNP's for IQ and those for ice cream preference to determine which is the "smarter" flavor.

1 comment:

  1. Eesh. This reminds me of working n a psych lab, where the PI would come back optimistic because more of the articles were "doing the math right."

    ReplyDelete