The Intelligence Gene Shell Game

A literature review looking at GWAS for "intelligence" brings home the point I try to make regularly on this blog:

Data on 17 published intelligence GWASs (3 of which reported no associations whatsoever) were downloaded from the GWAS Catalog and analyzed in the current study. Results show a generally low rate of replication: over 87% of the 2,335 included SNPs were reported only once, and only 4 of the 17 studies included follow-up testing in a replication sample. Of these 4, none found any replicable genome-wide significant hits.