This Study used the best polygenic risk score (PRS) to try and predict schizophrenia for a large group of individuals. Let's just cut to the chase, here:
For all outcomes investigated, the SCZ PRS did not improve the performance of predictive models, an observation that was generally robust to divergent case ascertainment strategies and the ancestral background of the study participants.
At this point, it is denial to believe that PRS is ever going to have any real use for schizophrenia or other classified mental disorders. The reason for this is that these traits are not related to genetic variants. The entire premise of PRS is a flawed idea for behavioral genetics. Let me add that if you let your diagnosis be influenced by polygenic scores (which you shouldn't based on this study, but you know how these go), then you will create a self-fulfilling prophecy of PRS predicting schizophrenia.
So sir, what do you think causes mental health problems if not genes ??? Are they psychological problems?? Can u suggest some books or references to these topics.
ReplyDeleteHello, I have read your review of The Genetic Lottery with interest and share your criticisms. What do you think about epigenetics and other non-DNA based cellular inheritance structures? Couldn't they at least partly explain the missing heritability? And the elusiveness of this heritability, since it is presumably easily modified across generations and possibly in some cases by lifetime experiences? (Juliette Colinas)
ReplyDeleteThe missing heritability, in my view, is due to inflated heritability estimates derived from twin studies.
DeleteThe missing heritability, in my view, is due to inflated heritability estimates derived from twin studies.
DeleteThe missing heritability, in my view, is due to inflated heritability estimates derived from twin studies.
Delete