Showing posts with label intelligence. Show all posts
Showing posts with label intelligence. Show all posts

Thursday, June 7, 2018

Another GWAS meta-analysis that suggests replications when the opposite is the case

"Since the discovery of general cognitive ability (or ‘g’) in 1904..."  (When I read a sentence like this, I am already a bit leery of what will come next.)

This critique is for the following study: 

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.  Gail Davies, et al.

This study is a meta-analysis of several studies I have already critiqued, here, here and here, as well as some new cohorts.  If I understand correctly, the new ones are the CHARGE and COGENT cohorts, but  in any case, it does not appear that any of the new datasets were ever studied independently related to cognitive ability and were simply added to the N of the meta-analyis.  I have a problem with this, which hopefully will become obvious as you read this critique. 

Sunday, April 29, 2018

Another Genetics and Intelligence GWAS/Meta-Analysis

I have been hoping to look at more studies based on intelligence and genetics, and tried to reach out to scientists and authors touting genetic evidence for intelligence to cite specific studies that they find convincing.  I have received no reply to my request, so for now I will pick and choose as I see fit.  I take, and prefer, requests, however.

This critique is for the following study:

A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence (Hill et al., 2017)
It is another GWAS/meta-analysis study.  Anyone who is following my critiques on this blog will probably assume, correctly, that I am going to harp on the lack of a random control.  I'll get to that, but wanted to make a few comments, first.

Sunday, April 22, 2018

Educational Attainment genes or a whole lot of nothing

I took a look at this study, because I was told that there are some really fantastic studies related to genetics and intelligence/educational attainment that have come out since 2015.  This one is from 2016.  I am very unimpressed:

Genome-wide association study identifies 74 loci associated with educational attainment

Each of the studies I've looked at so far involving GWAS have a fundamental problem right up front and this one is not an exception.