Towards Reproducible Brain-Wide Association Studies
The operative word here is "towards," since such studies approach, but never seem to achieve, reproducibility. They are inherently flawed, both in the tarot card method of reading them and simply because they are trying to capture something that doesn't exist. I'll lay down my Third Law of the Behavior Genetics Fallacy again:
Differences in human behavior, intelligence and personality are not accounted for by structural or functional differences in the brain.
In this particular study, they point out the limitations of low N studies of this nature:
In smaller samples, typical for brain-wide association studies (BWAS), irreproducible, inflated effect sizes were ubiquitous, no matter the method (univariate, multivariate).
The implication here is that larger N's will start to produce replicable results. Again, this has been the shell game for decades. What can we say about all the studies that were previously touted in this genre and are now shown to be defunct, like a dead salmon (ht Ben from Twitter).
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